2016b and 2019b Search Results


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Investigational drugs for treatment-resistant depression reviewed in this article.
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Investigational drugs for treatment-resistant depression reviewed in this article.
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Investigational drugs for treatment-resistant depression reviewed in this article.
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Image Search Results


KEY RESOURCES TABLE

Journal: Neuron

Article Title: Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains

doi: 10.1016/j.neuron.2021.06.010

Figure Lengend Snippet: KEY RESOURCES TABLE

Article Snippet: MATLAB 2016b and 2019b , Mathworks , RRID: SCR_016098 https://www.mathworks.com/products/matlab.html.

Techniques: Recombinant, Software

Investigational drugs for treatment-resistant depression reviewed in this article.

Journal: Expert review of neurotherapeutics

Article Title: Investigational drugs in recent clinical trials for treatment-resistant depression

doi: 10.1080/14737175.2017.1283217

Figure Lengend Snippet: Investigational drugs for treatment-resistant depression reviewed in this article.

Article Snippet: The study was recently completed, but results are not yet posted on ClinicalTrials.com. table ft1 table-wrap mode="anchored" t5 caption a7 Compound Sponsor Identifier Primary outcome Time frame N a Results or status Glutamatergic agents AVP-923 James Murrough (NY, USA) {"type":"clinical-trial","attrs":{"text":"NCT01882829","term_id":"NCT01882829"}} NCT01882829 MADRS e 10 W 20 March 2016 b AVP-786 Avanir (USA) {"type":"clinical-trial","attrs":{"text":"NCT02153502","term_id":"NCT02153502"}} NCT02153502 MADRS e 10 W 200 March 2016 b CERC-301 Cerecor (USA) Reference [ 84 ] HDRS-17 d 5 W 137 NS Cerecor (USA) {"type":"clinical-trial","attrs":{"text":"NCT02459236","term_id":"NCT02459236"}} NCT02459236 Bech-6 f 4 D 104 September 2016 b AV-101 National Institute of Mental Health (USA) {"type":"clinical-trial","attrs":{"text":"NCT02484456","term_id":"NCT02484456"}} NCT02484456 HDRS d Multiple 25 December 2019 b AZD6765 Astra-Zeneca (UK) Reference [ 89 ] MADRS e Multiple 22 Small, transient effect j Rapastinel Allergan (USA) {"type":"clinical-trial","attrs":{"text":"NCT01684163","term_id":"NCT01684163"}} NCT01684163 HDRS d 16 W 369 April 2014 b RO4995819 Hoffmann-La Roche (Switzerland) 2011–002160-24 g MADRS e 6 W 340 Terminated Other psychotropic drugs Ziprasidone Massachusetts General Hospital (USA) Reference [ 96 ] HDRS d 8 W 139 ZIP = 35% PL = 20% c , i Psilocybin Imperial College London (UK) Reference [ 100 ] Psychedelic PDE h 12 Ongoing Somatic drugs Minocycline Charite University (Germany) {"type":"clinical-trial","attrs":{"text":"NCT02456948","term_id":"NCT02456948"}} NCT02456948 MADRS e 6 W 160 February 2019 b Tocilizumab Brigham and Women’s Hospital (USA) {"type":"clinical-trial","attrs":{"text":"NCT02660528","term_id":"NCT02660528"}} NCT02660528 HDRS d 8 W 15 June 2017 b Sirukumab Janssen-Cilag International (Poland) 2014–005206-3 g HDRS d 12 W 192 Ongoing Open in a separate window a Enrolment (final or estimated). b Primary completion date (past or estimated). c Statistically significant. d Hamilton Depression Rating Scale. e Montgomery–Asberg Depression Rating Scale. f 6-item unidimensional subset of the HDRS-17. g Eudra identifier. h Peak drug effects. i Percent of responders (see text). j See text.

Techniques: Bioprocessing

Investigational drugs in phase II trials for treatment-resistant depression (2014 and later).

Journal: Expert review of neurotherapeutics

Article Title: Investigational drugs in recent clinical trials for treatment-resistant depression

doi: 10.1080/14737175.2017.1283217

Figure Lengend Snippet: Investigational drugs in phase II trials for treatment-resistant depression (2014 and later).

Article Snippet: The study was recently completed, but results are not yet posted on ClinicalTrials.com. table ft1 table-wrap mode="anchored" t5 caption a7 Compound Sponsor Identifier Primary outcome Time frame N a Results or status Glutamatergic agents AVP-923 James Murrough (NY, USA) {"type":"clinical-trial","attrs":{"text":"NCT01882829","term_id":"NCT01882829"}} NCT01882829 MADRS e 10 W 20 March 2016 b AVP-786 Avanir (USA) {"type":"clinical-trial","attrs":{"text":"NCT02153502","term_id":"NCT02153502"}} NCT02153502 MADRS e 10 W 200 March 2016 b CERC-301 Cerecor (USA) Reference [ 84 ] HDRS-17 d 5 W 137 NS Cerecor (USA) {"type":"clinical-trial","attrs":{"text":"NCT02459236","term_id":"NCT02459236"}} NCT02459236 Bech-6 f 4 D 104 September 2016 b AV-101 National Institute of Mental Health (USA) {"type":"clinical-trial","attrs":{"text":"NCT02484456","term_id":"NCT02484456"}} NCT02484456 HDRS d Multiple 25 December 2019 b AZD6765 Astra-Zeneca (UK) Reference [ 89 ] MADRS e Multiple 22 Small, transient effect j Rapastinel Allergan (USA) {"type":"clinical-trial","attrs":{"text":"NCT01684163","term_id":"NCT01684163"}} NCT01684163 HDRS d 16 W 369 April 2014 b RO4995819 Hoffmann-La Roche (Switzerland) 2011–002160-24 g MADRS e 6 W 340 Terminated Other psychotropic drugs Ziprasidone Massachusetts General Hospital (USA) Reference [ 96 ] HDRS d 8 W 139 ZIP = 35% PL = 20% c , i Psilocybin Imperial College London (UK) Reference [ 100 ] Psychedelic PDE h 12 Ongoing Somatic drugs Minocycline Charite University (Germany) {"type":"clinical-trial","attrs":{"text":"NCT02456948","term_id":"NCT02456948"}} NCT02456948 MADRS e 6 W 160 February 2019 b Tocilizumab Brigham and Women’s Hospital (USA) {"type":"clinical-trial","attrs":{"text":"NCT02660528","term_id":"NCT02660528"}} NCT02660528 HDRS d 8 W 15 June 2017 b Sirukumab Janssen-Cilag International (Poland) 2014–005206-3 g HDRS d 12 W 192 Ongoing Open in a separate window a Enrolment (final or estimated). b Primary completion date (past or estimated). c Statistically significant. d Hamilton Depression Rating Scale. e Montgomery–Asberg Depression Rating Scale. f 6-item unidimensional subset of the HDRS-17. g Eudra identifier. h Peak drug effects. i Percent of responders (see text). j See text.

Techniques: